Mansion Sports – The Premier League is once again set alight. In the second matchweek of the 2025/2026 season, Newcastle United will host Liverpool at St James’ Park on Monday, August 25, 2025, at 20:00 local time. 

This clash has become one of the most highly anticipated fixtures, particularly as both teams share a history of meetings filled with drama and intensity. Before the game begins, here is the predicted lineup for Newcastle United vs Liverpool 2025.

Newcastle Still Overshadowed by the Absence of Alexander Isak

The Magpies opened their campaign with a goalless draw against Aston Villa. Their attacking line looked less sharp, even though the arrival of new signing Anthony Elanga injected a sense of freshness into the squad.

However, the absence of Alexander Isak due to personal reasons remains a significant obstacle for Eddie Howe.

To overcome this void, Howe may turn to Anthony Gordon as a central striker or give an opportunity to William Osula. In midfield, Jacob Ramsey is expected to be included in the squad, while Joe Willock, who has just returned from injury, also has the potential to feature.

Liverpool Enter the Match with High Confidence

Liverpool, on the other hand, began their season with a convincing 4-2 victory over Bournemouth. Federico Chiesa and Mohamed Salah secured the win with late goals, while Hugo Ekitike once again displayed his potential as a dangerous young forward.

Nevertheless, injuries continue to cast a shadow over Arne Slot’s side. The absence of Jeremie Frimpong will undoubtedly be felt, particularly as Joe Gomez—who may be deployed as a replacement—is not yet fully fit.

The good news for the Reds is that Ryan Gravenberch has returned from suspension and is ready to reinforce the midfield.

Predicted Lineups Newcastle United vs Liverpool 2025

Newcastle United (4-3-3)

• Goalkeeper: Pope
• Defenders: Trippier, Schar, Burn, Livramento
• Midfielders: Guimaraes, Tonali, Joelinton
• Forwards: Elanga, Gordon, Barnes
• Manager: Eddie Howe
• Team information: Isak (personal reasons), Willock (doubtful)

Liverpool (4-2-3-1)

• Goalkeeper: Alisson
• Defenders: Gomez, Konate, Van Dijk, Kerkez
• Midfielders: Gravenberch, Mac Allister
• Attacking Midfielders: Salah, Wirtz, Gakpo
• Forward: Ekitike
• Manager: Arne Slot
• Team information: Frimpong (injured), Gomez (doubtful), Bradley (doubtful)

A Prestige-Filled Clash with the Potential for Drama

Last season, the battle at St James’ Park ended in a spectacular 3-3 draw. This time around, with Liverpool’s attacking line bolstered by the presence of Florian Wirtz and Hugo Ekitike, combined with Newcastle’s determination to defend their home ground, the match is expected to once again deliver an intense tactical showdown and thrilling goals.

The question remains: are you ready to witness this high-stakes encounter? St James’ Park is certain to be the stage for a fiery duel that could shape the early direction of both teams’ journeys in the new season.