Mansion Sports – The UEFA Champions League once again delivers high tension and unpredictable storylines. In the 2025/2026 campaign, Inter Milan will host Liverpool in one of the most anticipated fixtures of the round.

The match is set to take place at San Siro on Tuesday, 9 December 2025, with kickoff scheduled for 21:00 local time.

Amid internal uncertainty, Liverpool must navigate a challenging away fixture in Milan, while Inter aim to regain momentum at home after suffering their first defeat in the Champions League league phase this season.

Team Conditions Ahead of the Match

Inter Milan

Inter Milan recently suffered a disappointing 2–1 defeat to Atletico Madrid, with the decisive goal arriving deep into stoppage time.

However, that setback did not trigger the level of concern that followed their earlier heavy loss to PSV.

Before that defeat, Cristian Chivu’s side delivered an impeccable European run with victories over Kairat, Union SG, Slavia Prague, and Ajax.

They now sit fourth in the 36-team standings, level on points with Bayern Munich, Real Madrid, and Paris Saint-Germain, and three points behind leaders Arsenal.

Following their Champions League defeat, Inter responded convincingly with three consecutive wins in Serie A and the Coppa Italia, recording an emphatic 11–1 aggregate scoreline, including a 4–0 triumph over Como.

Although Liverpool defeated Inter 2–0 at San Siro in the 2021–2022 season, the Nerazzurri have since developed formidable home form, winning 10 of their last 11 Champions League league-stage matches in front of their supporters.

Liverpool

Liverpool’s Champions League journey this season has been marked by dramatic swings. They produced a memorable victory over long-time rivals Real Madrid, only to then suffer a damaging 4–1 defeat to PSV Eindhoven at Anfield — a result that matched a 96-year-old negative record.

The heavy loss left Liverpool outside the top eight with nine points. Though they went on to remain unbeaten in three matches afterward, draws against Sunderland and Leeds United amplified concerns about their inconsistency.

Tensions escalated when Mohamed Salah, who was left out of the match against Leeds, publicly stated that he felt sacrificed and suggested his relationship with head coach Arne Slot had deteriorated. This has sparked speculation that the current campaign could be his final season at the club.

Despite these internal issues, Liverpool continue to pursue a fourth consecutive win over Italian opposition in European competition, although recent performances indicate that such a task will be demanding.

Predicted Lineups for Inter Milan vs Liverpool December 2025

Inter Milan (3-5-2)

Inter may be forced to make changes in their defensive unit. Manuel Akanji is reportedly ill and could miss the match, with Francesco Acerbi expected to replace him. 

Matteo Darmian and Denzel Dumfries have already been ruled out, alongside Tomas Palacios and Raffaele Di Gennaro.

Up front, Lautaro Martinez — who has scored his 11th goal of the season — remains the key attacking figure and has netted in each of his last five Champions League home appearances.

Inter Milan Lineup

Liverpool (4-2-3-1)

Liverpool travel to Milan without several important players. Mohamed Salah is not included in the squad, alongside Cody Gakpo, Wataru Endo, and Federico Chiesa.

Although Conor Bradley has returned to action, Jeremie Frimpong and Giovanni Leoni remain sidelined due to injury.

Bradley is expected to start at right-back, while Joe Gomez may be preferred over Ibrahima Konate, who has struggled for form.

Liverpool Lineup

The complete predicted lineups above offer a clear picture ahead of the highly anticipated meeting between Inter Milan and Liverpool. 

The match promises intensity from the opening whistle, with both sides entering the contest carrying distinct storylines and challenges.