Mansion Sports – The 2025/2026 UEFA Champions League season continues to deliver high-stakes encounters, and this time, Bayer Leverkusen are set to host Paris Saint-Germain (PSG) in what promises to be a captivating matchday three fixture. 

The match will take place at BayArena, Germany, on Tuesday, October 21, 2025, at 20:00 local time.

Both sides approach this match under contrasting circumstances. Bayer Leverkusen are still searching for their first victory in this year’s competition, while PSG aim to maintain their flawless record and reaffirm their dominance as Europe’s elite. 

With exceptional talent on both sides, this clash is expected to be rich in tactical nuance, intensity, and drama.

Before the action unfolds, here is Mansion Sports’ prediction for the Bayer Leverkusen vs PSG 2025 lineups.

Team Conditions Ahead of the Match

Bayer Leverkusen

Bayer Leverkusen began their Champions League campaign with an unconvincing start, managing only draws against PSV Eindhoven and FC Copenhagen in their first two matches.

Despite the lack of victories, Kasper Hjulmand’s side have displayed consistency, remaining unbeaten in their last five games across all competitions.

In their previous outing, Leverkusen demonstrated impressive resilience, twice coming from behind to secure a 2-2 draw against Copenhagen. 

However, this result has increased the pressure to claim all three points — failure to do so would mirror their disappointing 2016 campaign, when they went winless in their opening three group-stage fixtures.

Statistically, Leverkusen have a strong record against French opposition in this tournament, remaining unbeaten in their last five group-stage meetings with Ligue 1 clubs. 

Their home form also stands out as a major advantage — BayArena has proven to be a fortress, with just one loss in their last 17 European home matches and four consecutive clean sheets in last season’s group stage.

Unfortunately, injury issues continue to affect the squad. Key players such as Exequiel Palacios, Nathan Tella, and Jarell Quansah remain sidelined, while Patrik Schick and Martin Terrier are also unavailable due to thigh and Achilles injuries, respectively. 

Nevertheless, the red-hot form of Christian Michel Kofane, who has scored in three consecutive matches, provides a major boost for the hosts.

Paris Saint-Germain

Meanwhile, Paris Saint-Germain arrive in Germany as the defending Champions League winners, having recorded two straight victories in the group stage so far. 

They defeated Atalanta and Barcelona with commanding performances, including a dramatic comeback win against the Catalan giants.

Under Luis Enrique, PSG are currently unbeaten in their last 14 Champions League matches, winning 12 of them. 

Another victory over Leverkusen would see them equal their longest-ever winning streak in the competition — six matches, first achieved during the 1994 campaign.

Despite their impressive form, PSG’s record in Germany remains less convincing. In their last ten away matches against Bundesliga sides, Les Parisiens have managed only two victories and have never kept a clean sheet. 

They also continue to deal with injury setbacks, with Ousmane Dembélé, Joao Neves, and Marquinhos recovering from various issues.

Nevertheless, PSG’s youthful and dynamic attack makes them a constant threat. Senny Mayulu and Gonçalo Ramos were instrumental in the win over Barcelona, while Khvicha Kvaratskhelia and Bradley Barcola are expected to add creativity and pace from the wings.

With their blend of speed, technique, and tactical discipline, PSG remain one of the most dangerous teams in Europe.

Predicted Lineups for Bayer Leverkusen vs PSG 2025

Below are the predicted lineups for the Bayer Leverkusen vs PSG 2025 Champions League clash at BayArena.

Bayer Leverkusen (3-4-2-1)

Despite being hit by injuries, Hjulmand is expected to maintain an attacking setup, relying on Kofane as the main striker. 

The combination of Arthur and Grimaldo will be pivotal in both defensive stability and transition play down the flanks.

Paris Saint-Germain (4-3-3)

Even with some key absentees, Enrique has multiple tactical options. The attacking trio of Kvaratskhelia, Ramos, and Barcola will lead the offensive charge, while Hakimi and Mendes are expected to play crucial roles in supporting attacks and containing Leverkusen’s wing play.

Final Thoughts

The Bayer Leverkusen vs PSG clash on matchday three of the 2025/2026 Champions League promises to be more than just a tactical duel — it will be a test of mentality, depth, and consistency. 

Leverkusen will rely on their home advantage and youthful energy to challenge the reigning champions, while PSG aim to extend their dominance on the European stage.

With both lineups filled with top-class talent, the encounter at BayArena is set to deliver a fast-paced, high-intensity battle that could have major implications for Group C’s standings. 

The key question remains: Can Leverkusen end PSG’s unbeaten run, or will the French giants reaffirm their status as Europe’s most formidable side? All eyes will be on Leverkusen when the whistle blows on Tuesday night.