Mansion Sports – The 2025/2026 Serie A season continues to heat up with several thrilling fixtures on the schedule, and one of the most highly anticipated clashes of Matchday 8 is the encounter between AC Milan and Pisa. 

The match will take place at the iconic San Siro Stadium in Milan on Friday, October 24, 2025, at 20:45 local time.

This contest brings together two sides with very different stories — AC Milan, the current league leaders, will host Pisa, a newly promoted team still fighting to escape the bottom of the standings. 

Before the action begins, here is Mansion Sports’ comprehensive prediction and analysis of the AC Milan vs Pisa 2025 lineups.

Team Conditions Ahead of the Match

AC Milan

AC Milan have shown remarkable consistency since the start of the campaign. The Rossoneri remain unbeaten in their last seven matches across all competitions and currently sit on 16 points in the Serie A table. 

Their spirited victory over Fiorentina last weekend highlighted the resilience and tactical discipline of Massimiliano Allegri’s squad.

In that match, Milan initially fell behind before Rafael Leão stepped up as the hero with two decisive goals. 

His first strike marked the end of a 17-month goal drought at San Siro, symbolizing a major return to form for the Portuguese forward.

Allegri’s return to Milan’s helm has undoubtedly restored stability. Although the veteran coach has refrained from openly discussing the title race, his side’s solid performances have reignited fans’ hopes of a potential Scudetto challenge. 

With Leão in peak condition and Luka Modrić orchestrating play from midfield, Milan are widely tipped to extend their home winning streak to four matches.

Despite a relatively long list of injuries, the Rossoneri have managed to defeat Bologna, Napoli, and Fiorentina in recent weeks. 

Facing Pisa — a side still finding their rhythm in Serie A — Milan are expected to dominate once again in their quest to maintain top position.

Pisa

In stark contrast, Pisa are struggling to escape the relegation zone. History also appears unkind to them — out of 12 previous Serie A meetings, they have suffered 10 defeats and managed only two draws. Even more concerning, they have failed to score in nine of those matches against Milan.

Their start to the 2025/2026 season has been far from ideal. With only three points and three goals so far, Pisa are enduring the worst top-flight start in the club’s history. Since their promotion, they have yet to record a single league victory.

Under Alberto Gilardino, Pisa showed slight improvement last week after earning a goalless draw against Hellas Verona. 

Nevertheless, the result still left them anchored at the bottom of the table alongside Genoa and Fiorentina. 

With their defense conceding eight goals in their first three away matches, the task of taking points at San Siro appears to be an uphill battle.

Predicted Lineups for AC Milan vs Pisa 2025

Below is the predicted lineup for both sides ahead of their Serie A Week 8 encounter at San Siro:

AC Milan (Formation 3-5-2)

Although still at the top of the table, Massimiliano Allegri faces several injury concerns. Christian Pulisic, Adrien Rabiot, Pervis Estupiñán, and Ardon Jashari remain unavailable, while Ruben Loftus-Cheek continues individual training due to a muscle issue.

On a positive note, Christopher Nkunku has recovered from a toe injury and could make a return as a substitute. 

The attacking responsibilities will rest heavily on the shoulders of Rafael Leão and Santiago Giménez, who are expected to lead Milan’s frontline.

Pisa (Formation 3-5-1-1)

On the visitors’ side, Alberto Gilardino also has to contend with injury woes. Calvin Stengs, Tomas Esteves, and Mateus Lusuardi are still sidelined, with the latter recently ruled out until 2026.

There is, however, some good news — Idrissa Touré returns from suspension and is expected to slot straight into the right wing position. 

Gilardino will continue to rely on Stefano Moreo and M’Bala Nzola to spearhead the attack, while Inter loanee Ebenezer Akinsanmiro will serve as the creative hub in midfield.

Closing Thoughts

The AC Milan vs Pisa clash is shaping up to be one of the most intriguing fixtures of Serie A Matchday 8. 

For Milan, it represents an opportunity to extend their unbeaten run and strengthen their position at the summit of the league table. For Pisa, it serves as a crucial test to prove their worth and resilience in Italy’s top division.

With both lineups now projected, fans eagerly await the spectacle that will unfold at San Siro. Will Rafael Leão once again deliver a decisive performance, or can Pisa defy the odds and secure a stunning upset against the league leaders? The answers will soon be revealed when the whistle blows under the bright lights of Milan.